Abstract
Cardiovascular disease is the high incidence of disease in the world and has the high rate of mortality and morbidity. Therefore, researching new mechanisms of cardiovascular disease has been received the widespread attention. A large number of studies have shown that oxidative stress is one of the main mechanisms of cardiovascular disease occurrence and development. Excessive reactive oxygen species cause an imbalance in the body of oxidation and anti-oxidation, which causes tissue damage. NADPH oxidase is the principal source of reactive oxygen species, thereby, studying clearly the role of NADPH oxidase in cardiovascular disease has important clinical significance for preventing and treating cardiovascular diseases via controlling oxidative stress. We summarized the newest studies on the relationship between NADPH Oxidases and cardiovascular diseases, which provide an idea that NADPH Oxidases play an important role in cardiovascular disease occurrence and development. This idea may illustrate the new cardiovascular disease pathogenesis and discovering new methods for cardiovascular diseases prevention and treatment.
Highlights
Cardiovascular disease (CVD) is one of the important diseases in the world and damages human health
NOX1 mediating the expressions of vascular endothelial growth factor (VEGF) and the matrix metalloproteinase (MMPS) may increase the formation of reactive oxygen species, NOX1 promotes angiogenesis and tumor formation [18]
Studies have shown that the mitochondria O2 – mediated by ATP sensitive channels depending on nicotinamide adenine dinucleotide phosphate (NADPH) can activate the NOX2 in the cytoplasm, which promotes the development of oxidative stress production in endothelial cell and high blood pressure disease [23,24]
Summary
Cardiovascular disease (CVD) is one of the important diseases in the world and damages human health. A growing number of studies indicate that oxidative stress is an important factor for the occurrence and development of cardiovascular disease via vascular endothelial dysfunction, inflammation, apoptosis, cell migration, fibrosis, and angiogenesis in relation to vascular remodeling of hypertension [1,2]. It is important to research the role of NADPH oxidase in cardiovascular disease occurrence and development.
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