Abstract
In phagosome escape of pathogenic mycobacteria the role of type VII secretion systems (T7SS) seems to be very important. These systems and, in particular, the structural and functional variability of T7SS substrates belonging to the WXG100 superfamily are the focus of our research. The best studied example of Esx protein complex is the Mycobacterium tuberculosis pair ESAT-6 and CFP-10. The current model states that the secreted substrate ESAT-6 is required for membrane permeabilization whereas CFP-10 acts as a chaperone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
