The role of Monocyte Chemotactic Protein-3 (MCP3) in pyelonephritis patients in Al- Najaf Governorate, Iraq

Abstract

Pyelonephritis is a serious disease that is widespread in Iraq and is mostly caused by Gram-negative bacteria, which are highly contagious and can spread from an infected person to others. The aim of this article was to evaluate the immunomodulatory role of Monocyte chemotactic protein-3 (MCP3) in the blood serum of patients with acute pyelonephritis and chronic pyelonephritis. A group of patients suspected of having nephritis were sampled in Najaf city, Iraq. Clinical and biochemical tests were performed to confirm their infection. Where 30 patients had acute pyelonephritis and 30 patients had chronic pyelonephritis, in addition to 29 healthy people who were considered control. MPC-3 was measured in the serum of the affected person using ELISA technology. MPC3 levels were significantly elevated (P < 0.05) in the group of patients with pyelonephritis compared with the control group. The chronic pyelonephritis group showed higher levels of MPC-3 in blood serum (P < 0.05) compared to the acute pyelonephritis group. This study showed that MPC-3 is related to pyelonephritis and can be used to help in diagnose the disease.