Abstract
The present study revealed that the solubilization of a poorly soluble drug, Amphotericin-B (AmB) can be improved by lipid-bile salt mixed micelles and it was also noted that mixed micellar systems are thermodynamically stable relative to micellar systems. It was observed that the degradation or precipitation of AmB was significantly reduced when stored at 8°C. The mixed micellar systems composed of sodium desoxycholate with monoolein increased the solubilization of AmB by more than seven-fold as compared to nonmicellar systems.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
