Abstract
To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Prospective study; institutional review board-approved clinical trial. Tertiary care pediatric medical center. Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient. The efficacy and safety of mitomycin in the prevention of scar formation. All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes. Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement. Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
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