Abstract
The potential use of low-temperature plasma (LTP) for therapeutic purposes has aroused the concern of many researchers. This paper examines the effect of LTP on the morphofunctional state of human bone marrow stem cells (BMSC). It has been established that LTP-induced oxidative stress has a dual effect on the state of stem cells. On the one hand, a cell culture exposed to LTP exhibits the progression of a destructive processes, which is manifested by the perturbation of the cell’s morphology, the initiation of lipid peroxidation and the accumulation of products of this process, like diene conjugates and malondialdehyde, as well as the induction of mitochondrial dysfunction, leading to cell death. On the other hand, the effect of LTP on BMSC located at a distance from the plasma is accompanied by the activation of proliferative processes, as evidenced by the tendency of the activity of mitochondrial biogenesis and fission/fusion processes to increase. The paper discusses the role of mitochondria and reactive oxygen species (ROS) in the cellular response to LTP.
Highlights
The creation of highly selective drugs is inevitably accompanied by concomitant side effects.The most common manifestation of such effects is the body’s immune response, which includes overreaction of the immune system and individual intolerance to the drug
We have shown that low-temperature plasma (LTP) induces a variety of effects on mammalian cells, ranging from mitochondrial degradation and apoptosis due to the overproduction of hydrogen peroxide and lipid peroxidation to increased mitochondrial biogenesis and dynamics of the organelles, reflecting the tendency for increased cell proliferation due to the reactive oxygen species (ROS)-induced activation of the fibroblast growth factor (FGFb)
We studied the effect of LTP on the formation of reactive oxygen species in the peroxide is the most long-lived ROS form; we estimated the concentration of this compound
Summary
The creation of highly selective drugs is inevitably accompanied by concomitant side effects. The most common manifestation of such effects is the body’s immune response, which includes overreaction of the immune system and individual intolerance to the drug. Much attention is currently being paid to the search for new methods of non-drug treatment of pathological processes.
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