Abstract
Pyroptosis is a recently discovered aspartic aspart-specific cysteine protease (Caspase-1/4/5/11) dependent mode of gene-regulated cell death cell death, which is represented by the rupture of cell membrane perforations and the production of proinflammatory mediaters like interleukin-18(IL-18) and interleukin-1β (IL-1β). Mitochondria also play an important role in apoptotic cell death. When it comes to apoptosis of mitochondrion, mitochondrial outer membrane permeabilization (MOMP) is commonly known to cause cell death. As a downstream pathological process of apoptotic signaling, MOMP participates in the leakage of cytochrome-c from mitochondrion to the cytosol and subsequently activate caspase proteases. Hence, targeting MOMP for the sake of manipulating cell death presents potential therapeutic effects among various types of diseases, such as autoimmune disorders, neurodegenerative diseases, and cancer. In this review, we highlights the roles and significance of mitochondria in pyroptosis to provide unexplored strategies that target the mitochondria to regulate cell death for clinical benefits.
Highlights
Mitochondria are the major sites of cellular energy production through oxidative phosphorylation (Jusic and Devaux, 2020)
Combined with recent studies related to mitochondrial outer membrane permeabilization (MOMP), we further discussed the interaction between MOMP in mitochondrial pyroptosis and apoptosis, and emphasized that targeting mitochondria may as a promising strategy to change the occurrence and development of diseases by regulating cell death
We have introduced the types and regulation mechanisms of pyroptosis briefly and discussed the significant effect of mitochondria on apoptosis in this review
Summary
Qian Li 1†, Nengxian Shi 2†, Chen Cai 2†, Mingming Zhang 3, Jing He 2, Ying Tan 2* and Weijun Fu 2*. Reviewed by: Xing Chang, China Academy of Chinese Medical Sciences, China Corey Wright, Los Medanos College, United States. Specialty section: This article was submitted to Mitochondrial Research, a section of the journal
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