Abstract
In this paper, the effect of various doses of misoprostol on prophylaxis of experimental stress gastritis in rats has been studied and compared to the effect of various doses of sucralfate. The study were conducted in 56 female Sprague-Dowley rats. 18 animals acted as controls: ten were not exposed stress and eight were exposed only to stress.1 00μg/kg dose of misoprostol has been given to 9 animals and exposed to stress and 200μg/kg dose of misoprostol has been given to 9 animals and exposed to stress. Sucralfate has been given to 20 animals and exposed to stress; ten recieved 200mg/kg dose and ten received 500mg/kg dose. At the end of the stress period, every animal has been sacrificed and its stomach removed and examined; ulcer score has been determined for each animal. Ulcer scores were decreased significantly in the groups which were given misoprostol, and sucralfate, in relation to the stress only group (p<0.05). There were no significant difference between misoprostol and sucralfate groups (p<0.05). There were also no significant difference between the effects of various doses of misoprostol or sucralfate (p<0.05).
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