Abstract
Background: The relationship between stress, symptoms of inflammatory bowel disease (IBD), and depression has not previously been considered using the theory of subjective wellbeing (SWB) homeostasis as a conceptual framework. It is proposed that mindfulness, as a mechanism of down-regulating challenging emotion, can aid in the restoration of mood homeostasis and reduce symptoms of both psychological and physiological stress. The study aims to identify whether individuals with Crohn’s disease (CD) and co-occurring psychological depression or stress are experiencing the defeat of SWB homeostasis. Further, the study aims to test whether a Mindfulness Based Stress Reduction (MBSR) intervention can restore homeostasis. The study would also identify whether this restoration of homeostasis is associated with a reduction in disease symptomatology.
 Methods/Design: An exploratory randomised control trial with 40 participants recruited from public health gastroenterology patients and randomly allocated to an 8-week MBSR program or wait-list control. Measures of SWB, depression, stress, and C-reactive protein (CRP) levels will be collected prior to and after the intervention. Individual HPMood set points will be determined from affect data collected over 7 days through momentary sampling techniques prior to the commencement of the intervention. Measures will be repeated at 6-month follow-up. Following this, the wait-list group will be offered the same 8-week MBSR. Hypotheses will be tested using mixed ANOVA and clinical significance tests.
 Discussion: This study will be an important contributor to knowledge about psychological vulnerability and resilience for people with CD and will provide initial evidence that could contribute to the development of a larger future trial.
Highlights
Introduction to the body scanFormat/materials Homework tasksVideos, and introductory reading, participation in 30 minute body scan, group discussionReading, practice sheets2 “Attention and the Introduction to sitting Videos, formal sitting brain”meditation meditation practice (10 minutes), group discussion3 “Dealing with Thoughts”
This study will be an important contributor to knowledge about psychological vulnerability and resilience for people with Crohn’s disease (CD) and will provide initial evidence that could contribute to the development of a larger future trial
Given the prevalence of the disease in Australia, and the high levels of psychological symptoms associated with the condition, it is important that potential treatments that might help to improve both psychological and physiological outcomes are explored (Häuser et al, 2014; Lores et al, 2021)
Summary
Introduction to the body scanFormat/materials Homework tasksVideos, and introductory reading, participation in 30 minute body scan, group discussionReading, practice sheets2 “Attention and the Introduction to sitting Videos, formal sitting brain”meditation meditation practice (10 minutes), group discussion3 “Dealing with Thoughts”. Introductory reading, participation in 30 minute body scan, group discussion. Formal introduction Reading, practice to yoga practice (30 sheets minutes), group discussion. Mountain and Lake Reading, practice meditation, communication sheets calendar, group discussion. The relationship between stress, symptoms of inflammatory bowel disease (IBD), and depression has not previously been considered using the theory of subjective wellbeing (SWB) homeostasis as a conceptual framework. The study aims to identify whether individuals with Crohn’s disease (CD) and co-occurring psychological depression or stress are experiencing the defeat of SWB homeostasis. A systematic literature review confirmed the higher prevalence of anxiety and depression amongst patients with IBD than healthy controls, with the prevalence rising for those with active disease symptoms (Barberio et al, 2021; Mikocka-Walus, Knowles, et al, 2016)
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