Abstract
MicroRNAs (miRNAs) are small ribonucleic acid molecules that play a key role in regulating gene expression. The increasing number of studies undertaken on the functioning of microRNAs in the tumor formation clearly indicates their important potential in oncological therapy. Pancreatic cancer is one of the deadliest cancers. The expression of miRNAs released into the bloodstream appears to be a good indicator of progression and evaluation of the aggressiveness of pancreatic cancer, as indicated by studies. The work reviewed the latest literature on the importance of miRNAs for pancreatic cancer development.
Highlights
MicroRNAs are small ribonucleic acid molecules that play a key role in regulating gene expression
One mRNA molecule can be regulated by different miRNAs
The complexity of the regulatory function of miRNAs is supported by the fact that one miRNA can regulate different mRNAs in two ways: by their degradation or by repression of translation
Summary
Beata Smolarz 1, *,† , Adam Durczyński 2,† , Hanna Romanowicz 1 and Piotr Hogendorf 2. These authors contributed to this study and should be regarded as joint first authors
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