Abstract
Background The basal-like subtype of human breast cancers has no clinically defined marker profile. Recent studies have shown that Met as well as certain Src family kinases are over-expressed in basal-like breast cancers and correlate with disease progression and poor prognosis. Our group has also demonstrated a potential regulatory role of Stat3 on Met activation or turnover, adding to the previously identified roles of Stat3.
Highlights
The basal-like subtype of human breast cancers has no clinically defined marker profile
Recent studies have shown that Met as well as certain Src family kinases are over-expressed in basal-like breast cancers and correlate with disease progression and poor prognosis
Published: 4 April 2013 doi:10.1186/1753-6561-7-S2-P21 Cite this article as: Carefoot et al.: The role of Met, Src and Stat[3] in basal-like breast cancer invasion
Summary
The basal-like subtype of human breast cancers has no clinically defined marker profile. Recent studies have shown that Met as well as certain Src family kinases are over-expressed in basal-like breast cancers and correlate with disease progression and poor prognosis. Our group has demonstrated a potential regulatory role of Stat[3] on Met activation or turnover, adding to the previously identified roles of Stat[3]
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