Abstract
Obstructive sleep apnea (OSA) is a common condition that is characterized by intermittent and recurrent pauses in respiration results in multiple cycles of hypoxia/reoxygenation with an increased production of reactive oxygen species. The aim of the study was to evaluate serum levels of matrix metalloproteinase (MMP) 2 and MMP-9 as markers of oxidative stress in obese patients with OSA. Study was performed on 30 obese patients who had been referred to the Chest Department of Kasr Al-Aini Hospital for clinical suspicion of OSA to perform polysomnography. They were classified into two groups: cases group that consisted of 20 obese patients who were diagnosed as OSA and controls group that consisted of 10 obese individuals, without OSA. The two groups were subjected to the following: complete history taking, clinical examination, Epworth sleepiness scale, BMI (in kg/m2), polysomnographic study, spirometry, laboratory examination for estimation of arterial blood gases, and serum levels of MMP-2 and MMP-9 measurements using ELISA. In a comparison between cases and controls regarding serum levels of MMP-9, it was found that the mean value of MMP-9 among cases was 169.7 ± 135.22, which was higher than in controls as the mean value was 87.29 ± 34.01, and the difference was statistically significant. MMP-2 also was higher in cases than in controls. However, the differences were statistically insignificant. MMP-9 could be used as a marker of oxidative stress in OSA. Egypt J Broncho 2014 8:10–16
Highlights
In recent years, obstructive sleep apnea (OSA) has emerged as a major public health problem because of its profound impact on patients’ health and quality of life [1].Obesity is one of the most important risk factors for sleep-disordered breathing [2].Production of matrix metalloproteinase (MMP) 9 is stimulated by hypoxia and by several cytokines, such as IL-6 and TNF-a
They were classified into two groups: cases group that consisted of 20 obese patients who were diagnosed as Obstructive sleep apnea (OSA) and controls group that consisted of 10 obese individuals, without OSA
The mean age of patients was 51.40 ± 11.68 years, which was higher than that of controls (Table 2).The difference between the two groups was statistically insignificant. This is in agreement with the study by Peppard et al [8] who reported an increase in the prevalence of OSA with age, which could not be explained by other risk factors such as obesity
Summary
Production of matrix metalloproteinase (MMP) 9 is stimulated by hypoxia and by several cytokines, such as IL-6 and TNF-a. These cytokines are increased and hypoxia is induced by apnea and hypopnea during sleep in patients with OSA [3]. The included patients were classified into two groups: (1) Cases: it consisted of 20 obese patients (BMI>30). (2) Controls: it consisted of 10 obese (BMI>30) healthy individuals free from any known diseases without OSA (Apnoea Hypopnea Index (AHI)
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