The role of malondialdehyde in the evaluation of the treatment response in acute pulmonary thromboembolism

Abstract

Aims: To facilitate the early diagnosis of the related patient group by investigating the level of Malondialdehyde (MDA) in high-risk pulmonary thromboembolism (PTE). In addition, it was aimed to see the effect of treatment after acute PTE on oxidative stress and to evaluate whether it is associated with the development of chronic thrombus. Methods: This study was conducted prospectively in 44 patients diagnosed with PTE in single-center. At the time of diagnosis, after 6 months of follow-up and treatment, the MDA levels of the patients were evaluated together with the controlled tests. Results: MDA level was found to be a determinant in the estimation of high-risk PTE. In addition, MDA level was found to be higher at the time of diagnosis and after treatment in patients with chronic thromboembolism. Conclusion: MDA level is a guiding parameter in high-risk PTE. In addition, the continuation of oxidative stress in the case of chronic thrombus may be important in the remodeling of the precapillary pulmonary artery.