Abstract
Objective: to study the role of macroelements in the pathogenesis of bronchial asthma in children. Materials and methods: A total of 131 patients with different degrees of bronchial asthma severity were examined instantaneously. The reference group consisted of 31 children of the respective gender and age groups 1 and 2A. The average age of children was 11.83 ± 3.38 years old. All children in the cohort were given a comprehensive clinical-laboratory examination, peakflowmetry, pulsoxymetry, and spirometry. The study of mineral homeostasis in blood serum was carried out by X-ray fluorescence analysis. Statistical processing of the results was performed using the Statistica 10 and Microsoft Office Excel 2010, calculations were carried out in the program R. Results: It was found that the levels of potassium, phosphorus, and sulfur in children with bronchial asthma were elevated, while the levels of calcium, magnesium, and chlorine were reduced compared to the control group patients. The content of these macronutrients in patients with varying degrees of disease severity did not have significant differences. Conclusions: The data obtained on the changes in macro-element homeostasis indicate the important role of diselementosis in the pathogenesis of BA. It is a significant factor that contributes to the progression of chronic inflammation in bronchial organs that requires correction of therapy in children.
Highlights
Objective: to study the role of macroelements in the pathogenesis of bronchial asthma in children
Materials and methods: A total of 131 patients with di erent degrees of bronchial asthma severity were examined instantaneously. e reference group consisted of 31 children of the respective gender and age groups 1 and 2A. e average age of children was 11.83 ± 3.38 years old
It was found that the levels of potassium, phosphorus, and sulfur in children with bronchial asthma were elevated, while the levels of calcium, magnesium, and chlorine were reduced compared to the control group patients. e content of these macronutrients in patients with varying degrees of disease severity did not have signi cant di erences
Summary
Цель: изучение роли макроэлементов в патогенезе бронхиальной астмы у детей. Материалы и методы: проведено сплошное одномоментное обследование 131 пациента с бронхиальной астмы разной степени тяжести. Заключение: полученные данные свидетельствуют о важной роли дисэлементозов в патогенезе бронхиальной астмы, являясь весомым фактором, способствующим прогрессированию хронического воспаления в бронхах и требующим коррекции проводимой терапии у детей. Objective: to study the role of macroelements in the pathogenesis of bronchial asthma in children. Materials and methods: A total of 131 patients with di erent degrees of bronchial asthma severity were examined instantaneously. Results: It was found that the levels of potassium, phosphorus, and sulfur in children with bronchial asthma were elevated, while the levels of calcium, magnesium, and chlorine were reduced compared to the control group patients. It is a signi cant factor that contributes to the progression of chronic in ammation in bronchial organs that requires correction of therapy in children
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