Abstract
Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response.
Highlights
Methyltransferases are a compendium of diverse enzymes, most of which use Sadenosyl-methionine (Ado-Met) as a donor of methyl groups
The basic methyl group transfer reaction is the catalytic attack of a nucleophile on a methyl group to form methylated derivatives of proteins, lipids, polysaccharides, nucleic acids, and various small molecules
Small-molecule inhibitors are promising tools that allow for the probing functions of methyltransferases in diseases
Summary
Methyltransferases are a compendium of diverse enzymes, most of which use Sadenosyl-methionine (Ado-Met) as a donor of methyl groups. The in vitro studies showed that SET7/9 is able to methylate TAF7 at the lysine residue K5 [8], which points to SET7/9 being involved in the TAF7-dependent regulation of its target genes, in response to heat shock [56] (Table 1). YAP1 and TAZ are integral components of the β-catenin destruction complex while the β-catenin/TCF4 complex binds enhancer elements of the YAP gene to drive YAP expression in colorectal cancer cells [58,59] Taken together, these facts indicate that SET7/9 may be considered as one of the key regulators of the Wnt/β-catenin and Hippo signaling pathways. Catenin destruction complex while the β-catenin/TCF4 complex binds enhancer elements of the YAP gene to drive YAP expression in colorectal cancer cells [58,59] Taken together, these facts indicate that SET7/9 may be considered as one of the key regulators o7fotfh1e3 Wnt/β-catenin and Hippo signaling pathways.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
