Abstract
Abstract Little is known about how effector CD8 T cells obtain exogenous long chain fatty acids (LCFAs) during T cell activation. LCFAs assist with membrane biogenesis and are required for rapid proliferation as well as effector molecule generation. One potential mechanism of fatty acid import is in the form of lysophophatidylcholine (LPC) by lipid carrier major facilitator superfamily domain containing 2a (MFSD2A). Here, we show that MFSD2A is highly expressed in activated CD8 T cells. Conditional loss of MFSD2A caused an altered effector response and resulted in defective memory cell formation. Taken together, these data show MFSD2A and LPC play a role in CD8 T cell metabolomics. Our future studies will use mass spectrometry lipidomics and gene expression analysis to identify the mechanisms by which CD8 T cells use LCFAs to mount a robust immune response to infection.
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