Abstract
Breast cancer is the most common form of cancer in women around the world. The molecular mechanisms of this heterogeneous disease have been extensively investigated; but yet; It requires a lot of sensitive and specific markers for prognosis and early detection approaches. Non-protein coding RNAs known as lncRNAs have been reported in tumorigenic involvement so they can be used for therapeutic purposes. In the present study, the expression levels of CCAT1, PDCD4, PDCD4-AS1, and MEG3 LncRNA in adjacent tumor and breast tissue in 88 Iranian patients were evaluated by quantitative real-time PCR. CCAT1 was significantly expressed and PDCD4-AS1 decreased in tumor samples, PDCD4 and PDCD4-AS1 showed a positive correlation with each other, higher levels of PDCD4-AS1 were associated with better survival, tumor samples showed lower levels of PDCD4 in Showed comparisons with normal tissue. Our findings suggest that lncRNAs play an important role in controlling gene expression after transcription of major tumor suppressors or carcinogenic genes, leading to the development of triple-negative breast cancer (TNBC). In conclusion, this study investigated the prognostic role of lncRNA in breast cancer patients.
Highlights
Breast cancer (BC), the main cause of world cancer-related deaths in women, may be a popular and highly mortal malignancy[1, 2].As identifying molecular factors for BC treatment may help advance survival rates, further researches have attempted to find biological targets which might be utilized for early prognostic and diagnosis approaches[3, 4]
Multiple kinds of research have been conducted to investigate the function of dysregulated lncRNA expression in different kinds of human cancer types such as BC [30, 31] we have attempted to evaluate the molecular role of differentially expressed lncRNAs, to better understand the process leading breast cancer progression
Our results revealed that MEG3 had no expression either in healthy or in tumor tissues
Summary
Breast cancer (BC), the main cause of world cancer-related deaths in women, may be a popular and highly mortal malignancy[1, 2]. Programmed cell death, or Apoptosis, may be a crucial biological mechanism, which occurs during the diverse process from growth to tissue turnover[14]. The expression of apoptosis-related genes is closely regulated. One of the apoptosisassociated genes is programmed cell death 4 (PDCD4), which is up-regulated after apoptosis initiation. More understanding of the molecular pathway of Luminal A breast cancer and its related genetic disorders could help us to recognize prognostic and diagnostic biomarkers and effective therapy. The molecular mechanism underlying breast cancer, focusing on the luminal A subtype with the expression levels of 4 lncRNAs in tumor cells and adjacent normal tissues were examined. Decreased identified in a screen aimed to determine apoptosis-induced targets [25,26,27] Decreased it regulates the expression of its sense protein-coding partner, PDCD4
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