THE ROLE OF LOCAL ENDOTHELIAL SHEAR STRESS (ESS) IN THE DEVELOPMENT OF CORONARY ARTERY DISEASE IN CARDIAC TRANSPLANT PATIENTS: POSSIBLE MAGNIFICATION OF ESS PATHOBIOLOGIC EFFECT RELATED TO IMMUNOLOGIC FACTORS OF REJECTION

Abstract

Transplant (tplant) coronary artery disease (TCAD) is an immunologic phenomenon and a major cause of morbidity/mortality after heart tplant. Low ESS drives plaque behavior in native CAD, but its role in TCAD, with its prominent immunologic environment, has not been studied. We studied 21 pts (av