Abstract
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy. For decades, research into HNSCC invasion and metastasis has been dedicated to the study of protein-coding genes. Along with whole-genome and transcriptome sequencing development, long non-coding RNA (lncRNA) has attracted greater attention. Compelling evidence has proven the critical role of lncRNAs in the occurrence and development of HNSCC by means of epigenetic modifications, regulation of gene transcription, and post-transcription level. More importantly, crosstalk between lncRNAs and microRNAs was recently proven to regulate HNSCC metastasis through EMT modification. Based on these, this review summarizes the critical roles of lncRNAs in HNSCC metastasis and the crosstalk between lncRNAs and microRNAs as well as the detailed regulatory mechanism of the interaction. Thus, a deeper understanding of the lncRNA network in cancer metastasis is finally uncovered in order to provide a rationale and innovative concepts toward new therapeutic strategies for the highly metastatic HNSCC.
Highlights
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy and involves carcinoma of several anatomic sites, such as lip, oral cavity, pharynx, and larynx, with an annual incidence of ∼500,000 [1]
LncRNA’s Role in HNSCC Metastasis long non-coding RNA (lncRNA) and miRNA was recently mentioned, and emerging evidence shows that such crosstalk has a great effect on human cancer metastasis, partially through EMT regulation [7]
We summarize the correlation between lncRNA and EMT mediation and highlight the leading role of lncRNA/miRNA crosstalk in the metastasis of HNSCC
Summary
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy and involves carcinoma of several anatomic sites, such as lip, oral cavity, pharynx (nasopharynx, oropharynx, hypopharynx), and larynx, with an annual incidence of ∼500,000 [1]. It is essential to explore the detailed molecular mechanisms involved in cancer metastatic cascade so as to promote the development of target therapy and improve the overall survival of HNSCC. Mountains of evidence highlight the irreplaceable role of long non-coding RNA (lncRNA) in cancer metastasis, including HNSCC [4, 5]. Such transcripts are widely validated not to produce functional proteins, but regulate gene expression at multiple levels and participate in cancer evolution and development [6]. LncRNA’s Role in HNSCC Metastasis lncRNA and miRNA was recently mentioned, and emerging evidence shows that such crosstalk has a great effect on human cancer metastasis, partially through EMT regulation [7]. We summarize the correlation between lncRNA and EMT mediation and highlight the leading role of lncRNA/miRNA crosstalk in the metastasis of HNSCC
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
