Abstract
Preparation BZ-55 caused hypoglycemia in normal rabbits, potentiated the hypoglycemic effect of insulin and inactivated insulinase of the liver. Insulinase is not found in rabbits with fatty dystrophy of the liver caused by carbon tetrachloride intoxication. The hypoglycemic effect of insulin is increased. Administration of BZ-55 (Nadizan) does not cause any hypglycemic action and does not potentiate the effect of injected insulin, although the insular pancreatic apparatus is uninjured. These experiments permit to draw a conclusion that the hypoglycemic effect of BZ-55 is connected not only with the stimulation of the β-cells but also with the activation of the peripheral action of insulin. It is mainly caused by the inactivation of hepatic insulinase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
