Abstract
AbstractThe hydration capacity of each of four disintegrants including microcrystalline cellulose (Avicel PH102), corn starch, croscarmellose sodium (Ac-di-sol) and sodium starch glycolate (Primojel) was determined to express the hydrophilicity. The complete pore structure, and the water uptake of unmilled dicalcium phosphate dihydrate (Di-Tab) tablets containing one of above disintegrants at 15% w/w level were studied It was found that the majority of the tablet porosity was made up by macropores which were accessed by mercury intrusion There was no statistically significant difference among pore volume-size distributions of table samples The water uptake results were treated by the empirical form of Washburn liquid penetration equation with appropriate experimental setup. It was possible to determine the significance of the empirical parameters drawn from the equation It was found that the hydrophilic nature of excipients present in a tablet played a major role in water uptake phenomenon It was suggeste...
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