Abstract
Recent discoveries have emphazised the close connection between factors involved both in thrombogenesis and in atherogenesis. Lipoproteins seem to have a direct effect both n platelets and endothelial cells. LDL increases the sensitivity of platelets to aggregating substances and reduce the spontaneous release of prostacyclin (PGI2)from endo thelial cells. HDL may partially counteract this effect of LDL on endothelial cells grown in culture. Albumin bound fatty acids have also profound effects on platelet and endothelial cell function. The dual effects of the prostaglandin precursor fatty acids from the linoleic and linolenic sequences make these fatty acids crucial with regard to the Production of thromboxane A2 platelets and prostacyclin in endothelial cells. It is suggested that manipulation with the dietary fatty acid composition and other situations which will induce significant changes in the quantity and quality of plasma FFA may favour thrombus formation by disturbing the homeostatic balance between the function of platelets and endothelial cells.
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