Abstract
These experiments are concerned with the influence of limbic system structures upon the pituitary-adrenal cortical system. Electrical stimulation of the amygdala through chronic, indwelling electrodes in the conscious monkey produced marked acute elevations of plasma 17-OH-CS levels. If stimulation is prolonged for several hours, it is followed by a marked depression of 17-OH-CS levels. Stimulation of the distal tip of the hippocampus is associated with a slight, acute elevation, but this is followed by a delayed and prolonged suppression of 17-OH-CS levels that may last for several days after only 90 minutes of intermittent stimulation. In experiments with bilateral amygdalectomy, monkeys show a diminution of the acute
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