Abstract
白三烯（LTs）作为重要的炎症介质，在咳嗽变异性哮喘（CVA）的气道炎症、气道重塑、气道高反应性和慢性咳嗽中具有重要作用，但是否介导相关咳嗽受体敏感性增高存在较大争议，在气道及气道外过敏反应的发病机制及抗过敏治疗的作用也需进一步研究。CVA的临床表现较典型支气管哮喘轻，可能与炎症细胞致敏性弱和过敏体质弱有关。半胱氨酰白三烯受体1（CysLT(1)R）拮抗剂短期效果明确，但长期应用能否抑制或减缓病程进展仍不明确；部分患者治疗无效，可能与白三烯的其他亚型有关。CVA患者炎症指标界限的不明确使得特异性抗白三烯治疗的开始时机、使用剂量和维持时间皆缺乏定论。.
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