Abstract
AimInvestigate the renal function and modulation of epithelial transporters of rats with angiotensin‐induced hypertension.MethodsNormal 8‐week‐old male Wistar rats were divided in two groups: control (sham) or treated with 200 ng/kg/min of angiotensin II (ANG II) for 28 days, using osmotic minipumps. Blood pressure (BP) was monitored weekly by tail cuff plethysmography. Renal plasmatic flow (RPF) and glomerular filtration rate (GFR) were determined by para‐aminohippurate sodium and inulin clearance, respectively. The excretion of ions was analyzed and proteic expression of renal transporters or ANG II receptors will be analyzed by Western Blot technique.Results and DiscussionOur preliminary results animals showed that the dose of ANG II used is sufficient to induce hypertension [110 ± 1,6 (sham) n = 4 versus 158 ± 1,7 (ANG II) mmHg n = 4 *p<0,001]. Urinary Na+ and K+ were reduced in hypertensive rats. RPF and GFR were also reduced [RPF = 13,29 ± 0,8 (sham) n = 14 versus 6,48 ± 0,44 (ANG II) ml/min/kg n = 14 *p<0,001] and [GFR = 8,4 ± 0,52 (sham) n=14 versus 4,73 ± 0,52 (ANG II) ml/min/Kg n = 14 *p<0,001], suggesting changes in renal hemodynamics and tubular function. However, epithelial transporters will be analyzed in the renal cortex and medulla. Financial Support: CNPq and FAPESP
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