The role of Kallikrein-kinin System in the Immune Response of Nasal Papilloma and Adventitious Sinusitis

Abstract

The work was dedicated to study the possible interconnection between the enzymatic activity of kallikrein-kinin system and the activation of immune response of benign nasal papilloma and adventitious sinusitis. 64 patients with nasal papilloma and adventitious sinusitis have been examined for the enzymatic activity of kallikrein-kinin system and for the cellular and humoral immune responses, as well as 20 healthy. The enzymatic activity of kallikrein-kinin system and antibody response were investigated by using the sera or plasma samples. Cellular immune response was evaluated by analyzing of T- lymphocytes, B- lymphocytes and O- lymphocytes. Comparative analysis of kallikrein activity and cellular immune response showed that elevation of kallikrein activity was well correlated with activation of T- lymphocytes (r=0.896) and T-supressors (r=0.975), indicating that the activity of kallikrein may be important in modulation of T-cell response. In contrast, activation of kallikrein-kinin system was not associated with induction of B-lymphocytes (r=0.578), T-helpers (r=0.694) and O-lymphocytes (r=0.569). Analysis of kallikrein activity and humoral immune response in the same study group showed that induction of kallikrein-kinin system was associated with substantial elevation of IgA (r=0.785), in contrast to lower level of IgG and IgM expression.It is also revealed that there is a high correlation between kininase activity and the indices of B-lymphocytes (r=0.768), T-supressors (r=0.754) and concentration of IgA (r=0.889), IgG (r=0.995) and IgM (r=0.889), in it the kininase ferment plays an important part for the formation of IgG.Our data suggested that the kallikrein-kinin system may play a regulatory role in cellular and humoral immune response and such interconnection between these two systems could be used as additional criteria for the evaluation of immune status.