Abstract
Viscosupplementation (VS) is the intra-articular administration of hyaluronic acid (HA) to treat joint osteoarthritis (OA), with the aim of lubricating intra-articular space and promote viscoinduction. In this article we reviewed the latest scientific evidence on VS for the treatment of symptomatic OA. Despite the use of HA intra-articular injections for treating OA is growing, some controversial aspects about its efficacy and cost-effectiveness remain. Apart for knee, medical evidence is still sparse for most of the joint. These contradictory results from meta-analysis led several international societies to produce guidelines with conflicting recommendations. Whereas HA intra-articular injections are now considered effective and safe for mild to moderate knee OA, its utility in other joint is still questioned and matter of debate. Further prospective studies are warranted for a better understanding of VS clinical and molecular efficacy.
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