Abstract
Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.
Highlights
Nutrition is known to play an important role in human health, primarily in the context of preventing chronic disease development including cancer
ITCs are potent electrophiles derived from the breakdown process of GLs, which are abundant in cruciferous vegetables
They are currently considered as an important class of nutraceuticals, characterized by a wide range of properties suggesting their possible use in various industries ranging from food to medicine to clinical practice
Summary
Nutrition is known to play an important role in human health, primarily in the context of preventing chronic disease development including cancer. ITCs are mainly responsible for the flavour and odour of cruciferous vegetables and exert a wide range of bioactivities from defence against pathogens (in Brassica vegetables) for the prevention of cancer development [32] Among them, their anti-microbial, anti-oxidant and anti-inflammatory properties are of particular importance. Whileof increasing methyltransferase expression, against blocking lipopolysaccharide pro-inflammatory cytokine involves formation the in porcine inflammasome-originated diseases(LPS)-induced [56] Another mechanism binding to the monocyte-derived dendritic cells [55]. N-terminal proline residue of the macrophageand migration inhibitory factor modifying its structure and preventing its interaction with extracellular properties As such, it (MIF), is involved in various inflammatory diseases, like rheumatoid arthritis and receptors and other protein targets.
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