Abstract
The role of ion channels and transporters in cell proliferation and cancer
Highlights
The Research Topic Issue on Ion Transport in Cell Cycle and Cancer addresses classic issues in the field as well as it points to novel perspectives
The paper reviews what is known about the Vm changes during cell cycle and the implications of different types of ion channels in the cell cycle stages, cancer cell migration and the differentiation of cancer stem cells
That a wide variety of ion channel types affect the main hallmarks of cancer is suggested by Crottès et al (2013), who focus on the role of the sigma-1 receptor (Sig1R) in cancer cells
Summary
The Research Topic Issue on Ion Transport in Cell Cycle and Cancer addresses classic issues in the field as well as it points to novel perspectives. The role of Ca2+ in autophagy is related to the increasing recognition of the multiple functions of intracellular ion channels, which regulate ion transport across the membranes of cellular organelles. Leanza et al (2013) provide an updated overview of the role of ion channels in mitochondria, endoplasmic reticulum, nucleus, endosomes, and lysosomes, with special attention to the implications for the biology of cancer.
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