Abstract
The intestinal epithelial barrier has evolved to maintain a delicate balance between absorbing essential nutrients while preventing the translocation of intestinal microbiota, which contribute to inflammation occurence.In inflammatory bowel disease (IBD), disruptions of intestinal barrier result in increased intestinal permeability which promotes the exposition to luminal content and triggers an immunological response that promotes intestinal inflammation.IBD patients demonstrate increased intestinal paracellular permeability.Therefore, therapeutic target to restore the mucosal barrier may provide effective therapeutic and preventive approaches against IBD.This review examines the roles of the intestinal mucosal barrier on mechanisms underlying mucosal barrier dysfunction in IBD. Key words: Inflammatory bowel disease; Intestinal barrier; Tight junction; Cell membrane permeability
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