Abstract
Objective: This study was conducted to prove the role of interleukin-4 gene promoter polymorphisms in Graves’ disease patients in M Djamil General Hospital Padang, Indonesia.
 Methods: This study was conducted from August 2015 until December 2015 in the Internal Medicine Department in Dr. M. Djamil Hospital, Padang, West Sumatera, Indonesia. This study involved 15 patients with Graves’ disease and 15 normal subjects. We examined that IL-4 promoter gene polymorphism was examined with PCR.
 Results: Sequencing examination on IL-4 gene promoter resulted in 2 Single Nucleotide Polymorphism (SNP) motifs, which is rs2243250 and rs2070847. IL-4 SNP gene promoter polymorphisms rs2243250 and rs2070847 were found in both patient and control groups. TT is homozygous SNP polymorphisms. CT is heterozygous SNP polymorphisms. CC is wild type or no mutation SNP polymorphisms. Based on statistical tests, no difference in rs2243250 and rs2070847 SNP polymorphisms was found between patient and control group (p > 0.05).
 Conclusion: This study observed no difference in interleukin-4 gene promoter polymorphism between Graves’ disease patients and control group.
Highlights
Graves’ disease is a hyperthyroid state characterized by diffuse enlargement of thyroid gland due to immunological causes
The T-cell regulator function is to regulate the balance of T-helper 1 (Th1) and T-helper 2 (Th2) cells in antibody production [1,2,3,4,5]
Examination methods We examined that IL-4 promoter gene polymorphism was examined with PCR
Summary
Graves’ disease is a hyperthyroid state characterized by diffuse enlargement of thyroid gland due to immunological causes. The immunological process that underlies Graves’ disease is the low clonal T-cell regulator. There are several studies linking the genetic role of Graves’ disease. There are various genes related to autoimmune thyroid disease. These genes control immune responses such as major histocompatibility complex genes, T cell receptor genes, and antibody genes and genes that encode autoantigen targets in autoimmune thyroid disease. Recent studies have found that promoter gene polymorphisms are associated with Graves’ disease [6,7,8,9,10,11]
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