Abstract
Objective To observe the role of integrin-linked kinase (ILK) in the regulatory effects of protein kinase C (PKC) a and e calcium sensitivity during hemorrhagic shock in rats.Methods The superior mesenteric artery (SMA) from Wistar rats were adopted to observe the influence of inhibitor smooth muscle cells (VSMC) were used to measure the protein expression and activity of ILK after apply-and e agonist were weakened by the inhibitor of ILK,and the Emax of Ca2+ was decreased to 50.1% and 56.2% of normal control respectively (P<0.O1).(2) The protein expression and activity of ILK in VSMC were decreased 2 h after hypoxia, and increased by the agonists of PKCa 2 h following hypoxia.Conclusion PKCot and e regulates the calcium sensitization through changing the protein expression and activity of ILK following hemorrhagic shock in rats. Key words: Shock,hemorrhagic; Calcium; PKC; Integrin
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