The role of instrumental markers in assessment of microcirculation of type 2 diabetes mellitus patients

Abstract

Introduction. The development of diagnostic techniques of diabetes mellitus microvascular complications is an urgent task. One such method is laser Doppler flowmetry (LDF). Purpose was to analyze the correlations of clinical and laboratory parameters and LDF spectral parameters in patients with type 2 diabetes mellitus. Materials and methods. The study involved 50 patients with type 2 diabetes and diabetic foot syndrome. Microcirculation was assessed using the BIOPAC LDF 100C system. In parallel, monitoring of transcutaneous oximetry in the probed area was carried out using the TCM400 device. For correlation analysis, the Spearman correlation coefficient was used. Results. While studying, a positive correlation was noted between the contribution of pulse fluctuations and the duration of diabetes (p<0.05). For the level of glycosylated hemoglobin, it was positively correlated with the value of the contribution of pulsed fluxmotions and negatively correlated with the contribution of low-frequency fluxmotions and the fluxmotion index (p<0.05). When assessing transcutaneous oxygen tension, a negative correlation was found with the value of the contribution of pulse fluxmotions (p<0.05). These correlations can be explained in the light of modern concepts of the pathogenesis of type 2 diabetes mellitus microvascular complications. Conclusion. In the course of the work, spectral parameters of LDF were found correlated with clinical, laboratory, and instrumental parameters. The dynamics of changes in LDF parameters corresponds to the ideas about the pathogenesis of diabetic microangiopathy. A promising direction for further research is the study of the progressive development of diabetic microangiopathy and the role of individual pathogenetic factors in this process.