The role of increased serum creatinine level in adverse outcomes of endovascular revascularisation in patients with acute coronary syndrome

Abstract

Ischemic kidney damage as part of acute coronary syn-drome (ACS) largely contributes to the development of un-favorable outcomes not only of the underlying disease, but also of endovascular procedures, aggravating the patient’s condition and prognosis. This study is aimed at assessing the long-term results of coronary stenting for ACS in pa-tients with a sharp increase in serum creatinine levels wit-hin 48 hours after the intervention. Purpose: to evaluate the relationship between an increase in serum creatinine levels after coronary stenting of an infarct-related artery and the development of adverse outcomes in the long term. Materials and methods: 51 patients with ACS took part in the study. Serum creatinine was assessed before and wit hin 48 hours after coronary stenting. Subsequent-ly, after 3–6 months, patients underwent repeat coronary angiography to assess the patency of the coronary bed. Results: based on repeated coronary angiography, we identified the development of angiographic restenosis in those patients who demonstrated a significant increase in serum creatinine levels within 48 hours after stent implan-tation. In the group of patients without restenosis, creati-nine values before and after revascularization were com-parable. Conclusion: we noted that kidney damage due to acute coronary syndrome in combination with the intro-duction of a large volume of contrast agent can contribute to the development of unfavorable outcomes of coronary sten ting in the long term, namely, in-stent restenosis