Year-end Sale % OFF 
Abstract
Aims: The mechanisms involved in mycosis fungoides (MF) progression from early to advanced stages have not been completely clarified. In a previous experience, an increase in myeloid derived suppressor cells (MDSCs) was observed comparing patches/plaques to tumours. MDSCs are a heterogeneous group of cells whose antitumor response has been related to the activity of the immune checkpoints, such as programmed death-1 (PD-1) and its ligand (PD-L1), whose function is to physiologically depress immune cell response avoiding autoimmune phenomena. It has been hypothesised that the same mechanism is used by neoplastic cells to depress the anti-tumour response, gaining tumour advantages. Recently, immune checkpoint inhibitors have become available, changing the therapeutic scenarios in different types of cancer. Few data are present in the literature on PD-1 and PD-L1 expression in MF, mostly showing heterogeneous results. The aim of the present study was to assess immune checkpoint expression and role in MF.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
