The Role of IL-37 as an Anti-Inflammatory Biomarker in some Iraqi Rheumatoid Arthritis Patients and Its Correlation with DAS28

Abstract

Interleukin-37 (IL-37) is a new anti-inflammatory cytokine that inhibits immunological response and inflammation. The purpose of this study is to look into the role of IL-37 and if it correlates with disease activity in some Iraqi RA patients. The scope of the investigation comprised of 76 females with RA who are aged in the range of (45.38 ±1.23 years) and 40 individuals in the control group with age of (46.48 ± 2.02years). When compared to controls, the level of serum IL-37 was shown to be considerably elevated in RA patients. (49.16 ± 3.25pg/ml vs. 32.04 ± 2.22pg/ml; p ≤ 0.05). However, the DAS28 score results showed a non-significant difference between the mild and severe rheumatoid arthritis patients. There was a positive association, statistically significant between the DAS28 score and anti-CCP Abs, RF. A positive correlation between DAS28 and ESR. While non-significantly correlated between DAS28 and CRP, IL-37.