Abstract

The virulence of Group A Streptococcus (GAS) is due to multiple factors including the production of superantigens such as Streptococcus Pyrogenic Exotoxin A (SPEA). Superantigens activate the T-lymphocyte through a non-specific MHC-antigen presenting cell complex of which intercellular adhesion molecule-1 (ICAM-1) is a necessary component. We sought to determine the contribution of ICAM-1 in the host response to SPEA-producing and non-SPEA producing GAS.

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