Abstract
In this review, we pay attention to the role of the hypoxia-inducible factor (HIF) in the development of response of the organism to hypoxia. Special attention is given to the regulation of the cell responses to hypoxia in chronic peripheral artery disease in patients with diabetes mellitus (DM). Cells can survive by activation of a transcription of genes, involved in angiogenesis, glucose metabolism and cell proliferation. Artificial rising of concentration and activity of HIF stimulates an angiogenesis and improves ulcers healing of the lower extremities. The data of the literature are provided on the possible methods of increasing HIF concentration in tissues, which could be a new way to stimulate wound healing in the patients with DM.
Highlights
Special attention is given to the regulation of the cell responses to hypoxia in chronic peripheral artery disease in patients with diabetes mellitus (DM)
Cells can survive by activation of a transcription of genes, involved in angiogenesis, glucose metabolism and cell proliferation
Artificial rising of concentration and activity of hypoxia-inducible factor (HIF) stimulates an angiogenesis and improves ulcers healing of the lower extremities
Summary
1 Federal State Budgetary Institution «Privolzhsky Federal Research Medical Centre» 603155, Russion Federation, Nizhny Novgorod, Verhne-Volgskaya quay, 18 2 State budget health agency Nizhny Novgorod region «City Clinical Hospital No 30, Moscow district of Nizhny Novgorod» 605157, Russion Federation, Nizhny Novgorod, Berozovskaya street, 85 e-mail: flebolog@live.com
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
