The role of hyaluronidase in growth of Streptococcus intermedius on hyaluronate.

Abstract

S. intermedius, formerly part of the clinically important ‘S. milleri group’ of organisms, has been frequently associated with deep-seated, purulent abscesses of the liver and brain. The mechanisms by which this organism initiates disease are unclear, but earlier studies have indicated that production of haemagglutinating and immunosuppressive factors and glycosidic enzymes may play a role in the pathogenicity of this organism. Additionally, Unsworth5 noted the correlation between hyaluronidase-producing strains of ‘S. milleri’ and the presence of a purulent internal abscess and suggested a role for this enzyme in the disease process.