Abstract
THE ROLE OF HOST SOLUBLE INFLAMMATORY MEDIATORS INDUCED BY THE BCG VACCINE FOR THE INITIATION OF IN VITRO MONOCYTE APOPTOSIS IN HEALTHY BRAZILIAN VOLUNTEERS
Highlights
Tuberculosis (TB) is the second greatest killer worldwide that is caused by a single infectious agent
It is generally perceived that the Bacillus Calmette-Guerin (BCG) vaccine is not fully effective because of the absence of antigens commonly shared with M. tuberculosis, and that the rapid removal of BGC via systemic immunity, primarily targeting atypical environmental mycobacteria, reduces the vaccine’s effectiveness over time
Cell-Death ratio A better understanding of the pathways related to the in vitro cell-mediated immune responses in humans has been obtained for individuals, BCG-sensitized or not, which will assist in identifying the specific mechanisms that may confer protection against M. tuberculosis
Summary
Tuberculosis (TB) is the second greatest killer worldwide that is caused by a single infectious agent. Since Bacillus Calmette-Guerin (BCG) is the only vaccine against TB currently in use, studies addressing the protective role of BCG in the context of inducible inflammatory mediators are urgently required. Despite the continuous evolution of better management, new drug development, and additional diagnostic tools available in public health, tuberculosis (TB) still remains as a serious global problem. It is currently estimated that one third of the world population is infected with Mycobacterium tuberculosis and that 5–10 % of those infected will develop the disease during their life-time [2]. The current TB vaccine is M. bovis bacille CalmetteGuérin (BCG), and it has been employed for nearly a century to prevent the disease. More studies are required to better understand how BCG confers protection in humans
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