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Abstract
By means of 800 r whole-body x-irradiation, host defensive and immunologic responses were heavily suppressed. Fertilized ova from C57BL/6J, A/HeJ, and white albino mice were transplanted to the kidneys of x-irradiated mice from the same or different strains. At the time of peak growth the number of living trophoblastic cells in irradiated animals was higher than in nonirradiated animals. No malignant changes in trophoblastic cells were observed. This suggests that environmental factors related to the immunologic and defensi ve state of the host plays a significant role in the degree of growth, prolifera tion, and life-span of trophoblastic cells.
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