THE ROLE OF HISTOLOGICAL FINDINGS IN H. PYLORI-INDUCED GASTRITIS: CLINICAL IMPLICATIONS AND BEYOND

Abstract

This study aimed to determine the role of histological findings in H. Pylori-induced gastritis. This cohort study involved 80 patients of both genders. The patients were endoscopically and histopathologically examined and followed up within six months after treatment, from April 2023 to September 2023. Multiple biopsies were taken from different stomach regions and compared to the endoscopic findings. Eighty patients were enrolled with a mean age of 38.80±17.24 years. The study showed that most of the patients improved. There was a significant relationship between the histopathological grading of gastritis (Sydney system) and the degree of gastritis observed through an endoscope among H. Pylori intensity, chronic inflammation, neutrophil activation, glandular atrophy, and degree of gastritis. However, other parameters, such as intestinal metaplasia and surface epithelium damage of the Sydney system, revealed no significant relationship. Our study found a very strong positive correlation between the degree of gastritis (endoscope) and the degree of gastritis (histopathology) before treatment. There was also a significant relationship between the degree of induced gastritis in endoscopy and histopathology after treatment. The p-value was 0.003, and the two variables had a moderate positive correlation after treatment. It was concluded that biopsies performed during endoscopy are essential for diagnosing and treating gastritis and associated disorders. Healthcare providers can customize treatment regimens to target specific underlying causes and handle potential problems using the information gathered from biopsies.