Abstract
Human herpes virus-6 (HHV-6) and human herpes virus-7 (HHV-7) are immunomodulating viruses potentially affecting the nervous system. We evaluated the influence of HHV-6 and HHV-7 infections on fibromyalgia (FM) clinical course. Forty-three FM patients and 50 control group participants were enrolled. 39.50% (n = 17) FM patients had light A delta and C nerve fiber damage, 27.91% (n = 12) had severe A delta and C nerve fiber damage. 67.44% (n = 29) FM patients had loss of warm sensation in feet, loss of heat pain sensation, and increased cold pain sensation (34.90%, n = 15 in both findings). HHV-6 and HHV-7 genomic sequences in peripheral blood DNA in 23/43 (51.00%) and 34/43 (75.50%) of samples from FM patients and in 3/50 (6.00%) and 26/50 (52.00%) of samples from the control group individuals were detected. Active HHV-6 (plasma viremia) or HHV-7 infection was revealed only in FM patients (4/23, 17.40% and 4/34, 11.80%, respectively). A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). 23/43 patients from the FM group and control group participants HHV-6 and 34/45 HHV-7 did have infection markers. A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). No difference was found between detection frequency of persistent HHV-6 and HHV-7 infection between FM patients and the control group. Statistically significant correlation was observed between quantitation of changes in QST thermal modalities and HHV-6 infection. There was no correlation between A delta and C nerve fiber damage and HHV-7 infection.
Highlights
Fibromyalgia (FM) is a chronic pain disorder with unknown main symptoms of FM are diffuse musculoskeletal pain, faetiology which leads to disability and poor quality of life
More than 80% of 43 patients reported pain in different parts of their legs, with more than 70% in arms
Assessed by the 2010 American College of Rheumatology (ACR) FM diagnostic criteria symptom severity score, more than 80% of all patients reported thinking or remembering problems, muscle weakness, headache, numbness, dizziness, insomnia, or nervousness
Summary
Fibromyalgia (FM) is a chronic pain disorder with unknown main symptoms of FM are diffuse musculoskeletal pain, faetiology which leads to disability and poor quality of life. (2019) 25:194–207 headache (Ballantyne et al 2010; Lucas et al 2006; Wolfe et al 2010). The disorder mainly affects middle-aged females (Albin et al 2008). The frequency of the disease increases with age, as well as symptom severity and worsening of life quality (Ballantyne et al 2010; Balon and Wise 2015; Branco et al 2010; Jiao et al 2014). The prevalence of FM in the general population varies from 0.50 to 7.0% (Balon and Wise 2015)
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