Abstract
Background: Knowledge of HER2/Neu and BRCA1 Genes might be helpful for development of strategies for decreasing the burden of risk of breast cancer. Therefore, the aim of this study to detect the role of HER2/Neu and BRCA1 Genes expression in diagnosis of breast cancer in Sudanese women. Methodology: A total of 100 tissue samples obtained from patients with breast cancer in addition to 50 tissue samples obtained from patients with benign breast lesions, were detected the expression of HER2/Neu and BRCA1 Genes by Polymerase Chain Reaction (PCR). Results: The prevalence of HER2/Neu and BRCA1 Genes, among cases was 6%, and 10% respectively. Conclusion: HER2/Neu and BRCA1 Genes have a considerable contribution to etiology of breast cancer in Sudan that requires further consideration.
Highlights
Breast cancer is the most common cancer in women worldwide, leading to about 300,000 deaths each year
A total of 100 tissue samples obtained from patients with breast cancer in addition to 50 tissue samples obtained from patients with benign breast lesions, were detected the expression of human epidermal growth factor receptor 2 (HER2)/Neu and BRCA1 Genes by Polymerase Chain Reaction (PCR)
HER2/Neu and BRCA1 Genes have a considerable contribution to etiology of breast cancer in Sudan that requires further consideration
Summary
Breast cancer is the most common cancer in women worldwide, leading to about 300,000 deaths each year. It is considered a biologically heterogeneous disease that is influenced by complex and still incompletely understood interactions. These interactions may play an important role in the significant geographical differences in breast cancer incidence [1]. The BRCA1 tumor suppressor gene account for approximately 45% of families with a significantly high breast cancer incidence and the HER2/Neu oncogene is in proximity on the long arm of chromosome 17 (17q11-21) [4] [5]. Absence of BRCA1 or functional overexpression of the HER2/Neu gene may be characteristic of the somatic phenotype of breast cancer in premenopausal women, characterized by a poor prognosis, such as a high tumor grade, negative hormone receptors, and a high proliferation rate [6]
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