Abstract
Salvia plebeia R.Br. is a widely distributed grass, which has been used as a folk medicine for the treatment of hepatitis. In this study, a simple method for preparative separation of the flavonoid-rich extract of S. plebeia was established with macroporous resins, the method can be referenced for large-scale enrichment of flavonoid-rich extract from herbal raw materials. The major constituents of FESP, including luteolin-7-glucoside, nepetin-7-glucoside, homoplantaginin, luteolin, nepetin, and hispidulin were determined by HPLC-DAD analysis. The hepatoprotective effect of FESP was evaluated in carbon tetrachloride (CCl4)-induced liver injury in mice. The biochemical results were supplemented by histopathological examination. Key words: Hepatoprotective activity, Salvia plebeia R. Brown (Lamiaceae), flavonoids, histopathological.
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