Abstract
Hepatobiliary scintigraphy (HBS) has been demonstrated to predict post-hepatectomy liver failure (PHLF). However, existing cutoff values for future liver remnant function (FLR-F) were previously set according to the “50–50 criteria” PHLF definition. Methods of calculation and fields of application in liver surgery have changed in the meantime. The aim of this study was to demonstrate the role of HBS combined with single photon emission computed tomography (SPECT/CT) in predicting severity of PHLF, according to the International Study Group of Liver Surgery (ISGLS). All patients submitted to major hepatectomy with preoperative HBS-SPECT/CT between November 2016 and December 2019, were analyzed. Patients were resected according to hepatic volumetry. Receiver operating characteristic (ROC) curve analysis was performed to identify cutoffs of FLR function for predicting PHLF according to ISGLS definition and grading. Of the 38 patients enrolled, 26 were submitted to one-stage hepatectomy (living liver donors = 4) and 12 to two-stage procedures (portal vein embolization = 4, ALPPS = 8). Overall, 18 patients developed PHLF according to ISGLS criteria: 12 of grade A (no change in the patient’s clinical management) and 6 of grade B (change in clinical management). ROC analysis established increasingly higher cutoffs of FLR-F for predicting PHLF according to the “50–50 criteria”, ISGLS grade B and ISGLS grade A/B, respectively. HBS with SPECT/CT may help to assess severity of PHLF following major hepatectomy. Prospective multicenter trials are needed to confirm the effective role of HBS-SPECT/CT in liver surgery.
Highlights
Post-hepatectomy liver failure (PHLF) represents one of the most feared complications by liver surgeons
hepatobiliary scintigraphy (HBS) has been described in major hepatectomy as well as in liver regeneration techniques, such as portal vein embolization (PVE) [3], Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) [4] and more recently in liver transplantation (LT) setting [5]
The present study aims to assess the value of HBS combined with SPECT/CT in assessing PHLF according to International Study Group of Liver Surgery (ISGLS) criteria
Summary
Post-hepatectomy liver failure (PHLF) represents one of the most feared complications by liver surgeons. HBS has the advantage compared to other dynamic functional test, such as indocyanine green clearance (ICG) test, to measure the global liver function and to take into account regional variations that may occur within the liver. For this reason, HBS has been described in major hepatectomy as well as in liver regeneration techniques, such as portal vein embolization (PVE) [3], Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) [4] and more recently in liver transplantation (LT) setting [5]. Since the International Study Group of Liver Surgery (ISGLS) criteria to define PHLF [8] have been demonstrated to better perform than “50–50 criteria” in assessing severity of PHLF and are currently one of the most widely used criteria in clinical studies, the need to re-assess functional cutoffs to determine an adequate liver function is urgent
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