Abstract
The role of HDL in innate immunity
Highlights
HDL has anti-atherogenic properties that are primarily attributed to its key role in reverse cholesterol transport
Numerous studies have shown that lipoproteins bind microorganisms or compounds derived from microorganisms [3]
When either endotoxin (LPS), from gram negative bacteria, or lipoteichoic acid (LTA), from gram positive bacteria, are incubated with whole blood from healthy humans, the majority of the LPS and LTA are bound to HDL
Summary
HDL has anti-atherogenic properties that are primarily attributed to its key role in reverse cholesterol transport. Both apolipoproteins and phospholipids can play important roles in the ability of HDL to neutralize LPS [3]. They report that HDL isolated from endothelial lipase knockout mice is similar to HDL isolated from wildtype mice in the ability to facilitate cholesterol efflux, protect from oxidation, and inhibit the ability of cytokines to activate endothelial cells.
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