THE ROLE OF GROWTH FACTORS IN TROPHOBLAST INVASION AND THEIR ASSOCIATION WITH THE PATHOLOGICAL COURSE OF PREGNANCY

N G Prikhodko

doi:10.36604/1998-5029-2019-74-111-118

Abstract

The article presents a brief review of the literature on the role of growth factors in the processes of trophoblast invasion and their association with the pathological course of pregnancy. The importance of vascular endothelial growth factor, placental growth factor and vessels receptors, transforming growth factor, insulin-like growth factor in the development and differentiation of the placenta during physiological pregnancy are shown. There has been described violations that allow to assert the involvement of vascular growth factors and their receptors in the pathogenesis of placental insufficiency, preeclampsia, spontaneous miscarriage, fetal growth retardation. The analysis of the literature data concerning the role of growth factors in the processes of trophoblast invasion and various complications of the gestational period allowed to draw a conclusion about the insufficient study of this issue.

Highlights

The article presents a brief review of the literature on the role
described violations that allow to assert the involvement of vascular growth factors
The analysis of the literature data concerning the role of growth factors in the processes

Summary

Introduction

Роль факторов роста в инвазии трофобласта и их ассоциация с патологическим течением беременности // Бюллетень физиологии и патологии дыхания. For citation: Prikhodko N.G. The role of growth factors in trophoblast invasion and their association witn the pathological course of pregnancy. Растворимые изоформы VEGFR-1, VEGFR-2 осуществляют регуляцию активности PIGF и VEGF, что подтверждает факт вовлечения сосудистых факторов роста и их рецепторов в патогенез развития патологии прикрепления плаценты [6], угрозы выкидыша [24, 37], кардиоваскулярной патологии [10]. Исследования, проведенные у женщин на сроке гестации 18-22 недели показали высокий уровень в сыворотке крови VEGF и VEGFR-1, низкий уровень PlGF ассоциирован с плацентарными нарушениями во втором и третьем триместрах, задержкой роста плода, интранатальной асфиксией при нормальном весе плода, гипоксически-ишемической энцефалопатией новорожденных [23].

Results

Conclusion