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Abstract
The onset of mammalian puberty requires a sustained increase in the episodic secretion of luteinizing hormone-releasing hormone (LHRH) from the hypothaiamus. This change is not initiated by LHRH neurons themselves but is instead brought about by the activation of “upstream” regulatory elements located in cells functionally connected to the LHRH neuronal network. Until now, this entire control system was thought to be neuronal and to function exclusively via transsynaptic communication. Recent studies, however, have suggested that LHRH neuronal function is also controlled by molecules of glial origin. Transforming growth factor-α was identified as one of these regulatory signals and was shown to be involved in the control of both normal and precocious puberty. Transforming growth factor-α may epitomize a group of related glial-derived growth factors involved in the developmental control of LHRH release.
Published Version
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