Abstract
ABSTRACTObjective: This study was done to investigate the association between maternal serum glutathione peroxidase (GP) and late onset of severe preeclampsia. Methods: Cross-sectional study was undertaken comparing normal pregnancy and severe preeclampsia at 37–42 weeks of gestational age. Maternal venous blood was taken to assess the level of GP. Result: Twenty normal pregnancy and 20 severe preeclampsia patients were investigated. The median (max–min) of GP level for preeclampsia was 4.31 (0.03–327.41) mU/mL significantly lower than in normal pregnancy 318.90 (6.46–694.11) mU/mL (p < 0.001). A receiver operating characteristics (ROC) analysis showed that the cutoff point for GP to differentiate between normal pregnancy and severe preeclampsia was 41.74 mU/mL. Multivariate analysis was done to investigate the impact of BMI and parity showed that a low level of GP will increase the risk of severe preeclampsia. Conclusion: Low level of GP was associated with the diagnosis of severe preeclampsia.
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